Scavenger effect of sulphasalazine (SASP), 5-aminosalicylic acid (5-ASA), and olsalazine (OAZ)
نویسندگان
چکیده
منابع مشابه
Role of 5-aminosalicylic acid (5-ASA) in treatment of inflammatory bowel disease: a systematic review.
Authors' objectives To perform a systematic review of the efficacy of 5-aminosalicylic acid (5-ASA) compounds (oral and topical) in the treatment of inflammatory bowel disease (IBD), both ulcerative colitis (UC) and Crohn's disease (CD), in the acute phase for inducing remission and for the prevention of relapses or recurrences. Also, to evaluate the influence of several factors (such as dosage...
متن کاملPENTASA Tablets and Sachets NAME OF THE MEDICINE Mesalazine (5-ASA) Synonyms: 5-aminosalicylic acid 5-amino 2-hydroxybenzoic acid
PHARMACOLOGY Pharmacotherapeutic group: Intestinal anti-inflammatory agents (A07 EC02). Actions: It has been established that mesalazine is the active component of sulfasalazine, which is used for the treatment of ulcerative colitis and Crohn’s disease. Based on clinical results, the therapeutic value of mesalazine after oral as well as rectal administration appears to be due to a local effect ...
متن کاملControlled release of 5-aminosalicylic acid (5-ASA) from new biodegradable polyurethanes.
Segmented polyurethanes containing azo aromatic groups in the main chain were synthesized by reaction of 3,3'-azobis(6-hydroxybenzoic acid) (ABHB), 5-[4-(hydroxyphenyl)azo] salicylic acid (HPAS), and 5-[1-hydroxynaphthyl)azo] salicylic acid (HNAS) with hexamethylenediisocyanate (HDI). All synthesized monomers and polymers were characterized by elemental analysis, FTIR, 1H-NMR spectra, TGA and D...
متن کاملRelease of 5-Aminosalicylic Acid (5-ASA) from Mesalamine Formulations at Various pH Levels
INTRODUCTION Oral formulations of 5-aminosalicylic acid (5-ASA) for treatment of ulcerative colitis have been developed to minimize absorption prior to the drug reaching the colon. In this study, we investigate the release of 5-ASA from available oral mesalamine formulations in physiologically relevant pH conditions. METHODS Release of 5-ASA from 6 mesalamine formulations (APRISO®, Salix Phar...
متن کاملبررسی اثر 5- آمینوسالیسیلیک اسید(5-ASA) در آسیب ناشی از ایسکمی و رپرفیوژن در کلیه موش صحراییThe Assessment of 5-Aminosalicylic Acid(5-ASA) Effect on Ischemia-Reperfusion Injury of the Kidney in Rats
Background & Aim: Occlusion of organs artery results in ischemia and the opening of occluded artery leads to tissue lesion identified as reperfusion injury(RI). Oxygen-derived free radicals seem to be involved in the reperfusion injury. In this experimental study the effects of 5-aminosalicylic acid(5-ASA), a prescribed drug for ulcerative colitis, was assessed. 5-ASA is a potent scavenger ...
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ژورنال
عنوان ژورنال: Gut
سال: 1990
ISSN: 0017-5749
DOI: 10.1136/gut.31.6.730-b